Description
Cynomolgus Growth Hormone R (GHR) Protein, His Tag | GHR-C52H1-1mg| Gentaur Distribution US, UK & Europe
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Source: Cynomolgus Growth Hormone R, His Tag (GHR-C52H1) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Tyr 264 (Accession # EHH62357.1).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Phe 19 - Tyr 264.
Conjugate: Unconjugated.
Molecular Weight: 30.2 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.2 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
