Cynomolgus GDF-15 / MIC-1 Protein, His Tag | GD5-C5148-100ug

Cynomolgus GDF-15 / MIC-1 Protein, His Tag | GD5-C5148-100ug| Gentaur Distribution US, UK & Europe

Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.

Source: Cynomolgus GDF-15, His Tag (GD5-C5148) is expressed from E. coli cells. It contains AA Ala 197 - Val 308 (Accession # G7PWZ3-1).

Format: Powder.

Tag: N-10×His.

Expression System: E. coli.

Expression Region: Ala 197 - Val 308.

Conjugate: Unconjugated.

Molecular Weight: 14.4 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 14.4 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).

Purity: 95%.

Buffer: 0.085% TFA in 30% ACN.

Storage Conditions: -20℃.

Shipping Conditions: RT