Description
Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified) | CDB-C5224-100ug| Gentaur Distribution US, UK & Europe
Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
Source: Cynomolgus CD32b, His Tag (CDB-C5224) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 224 (Accession # Q8SPW3-1).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Ala 46 - Pro 224.
Conjugate: Unconjugated.
Molecular Weight: 21.8 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.8 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
