Description
Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified) | ALN-C52H5-1mg| Gentaur Distribution US, UK & Europe
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Source: Cynomolgus Alpha-Synuclein, His Tag (ALN-C52H5) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P61142-1).
Format: Powder.
Tag: C-10×His.
Expression System: E. coli.
Expression Region: Met 1 - Ala 140.
Conjugate: Unconjugated.
Molecular Weight: 16.4 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE).
Purity: 95%.
Buffer: 100 mM NaAC, pH7.0.
Storage Conditions: -20℃.
Shipping Conditions: RT
