CYLD Antibody | N1164-100UG

CYLD Antibody | N1164-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB

Buffer: 1X PBS, pH 7.4

Limitation: This CYLD antibody is available for research use only.

Purity: Protein A affinity chromatography

Description: CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

Immunogen: A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.

Storage: Aliquot the CYLD antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.