Cyclin E1 Antibody / CCNE1 | V9178-100UG

Cyclin E1 Antibody / CCNE1 | V9178-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: CCNE1/4935R

Host: Rabbit

Clonality: Recombinant Rabbit Monoclonal

Isotype: Rabbit IgG

Species Reactivity: Human

Application: WB, IHC-P

Application Details: Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml

Application Note: Optimal dilution of the recombinant CCNE1 antibody should be determined by the researcher.

Purity: Protein A/G affinity

Description: Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

Immunogen: A portion of amino acids 10-176 was used as the immunogen for the recombinant CCNE1 antibody.

Storage: Aliquot the recombinant CCNE1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Localization: Nuclear