Cyclin E1 Antibody / CCNE1 | V8192-20UG

Cyclin E1 Antibody / CCNE1 | V8192-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: CCNE1/2587

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA

Buffer: N/A

Limitation: This Cyclin E1 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

Immunogen: A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.

Storage: Store the Cyclin E1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).