Cyclin D1(DCS-6), CF640R conjugate, 0.1mg/mL Antibody | BNC400007-100

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SKU:
37-BNC400007-100
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IN STOCK
Weight:
1.00 KGS
€418.00
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Description

Cyclin D1(DCS-6), CF640R conjugate, 0.1mg/mL Antibody | BNC400007-100| Gentaur Distribution US, UK & Europe

Summary.: Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. .

Conjugate: CF640R.

Storage Buffer: PBS, 0.1% BSA, 0.05% azide.

Storage Temperature: 2°C to 8°C.

Application: Flow, intracellular (verified)|IHC, FFPE (verified)|WB (verified).

Stability: Stable at room temperature or 37°C (98°F) for 7 days.

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Additional Information

Size:
100 uL
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