Cyclin D1 Antibody / CCND1 | V2006IHC-7ML

Cyclin D1 Antibody / CCND1 | V2006IHC-7ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

Format: Purified

Clone: DCS-6

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse, Rat

Application: IHC-P

Buffer: N/A

Limitation: This Cyclin D1 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This antibody recognizes a protein of 36kDa, identified as Cyclin D1. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms and a key cell cycle regulator. This antibody neutralizes the activity of Cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. Cyclin D1 antibody is useful in identifying mantle cell lymphomas, which stain positive, from CLL/SLL and follicular lymphomas, which stain negative. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Immunogen: Human recombinant full length protein was used as the immunogen for this Cyclin D1 antibody.

Storage: Store the Cyclin D1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).