Description
Cyclin D1 Antibody (CCND1) | F52187-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, ELISA
Buffer: N/A
Limitation: This CCND1 antibody is available for research use only.
Purity: Antigen affinity
Description: Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Immunogen: A portion of amino acids 264-292 from the human protein was used as the immunogen for this CCND1 antibody.
Storage: Aliquot the CCND1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
