Cyclin D1 Antibody (CCND1) | F48111-0.08ML

Cyclin D1 Antibody (CCND1) | F48111-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, IHC, IF, ELISA

Buffer: N/A

Limitation: This Cyclin D1 antibody is available for research use only.

Purity: Antigen affinity

Description: CCND1 is the regulatory component of the Cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. CyclinD-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. [UniProt]

Immunogen: A portion of amino acids 68-97 from the human protein was used as the immunogen for this Cyclin D1 antibody.

Storage: Aliquot the Cyclin D1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.