Description
Cubilin Antibody / CUBN | RQ4757 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: GA-3
Host Animal: Rabbit
Clonality: Rabbit Monoclonal
Species Reactivity: Human
Application: IHC-P, WB
Buffer: N/A
Limitation: This CUBN antibody is available for research use only.
Purity: Affinity purified
Description: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. [UniProt]
Immunogen: A synthetic peptide specific to human Cubilin / CUBN was used as the immunogen for the CUBN antibody.
Storage: Store the CUBN antibody at -20 °C.
