Description
CTSD Antibody / Cathepsin D | V7476-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: CTSD/2781
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P, WB
Buffer: N/A
Limitation: This Cathepsin D antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Immunogen: A portion of amino acids 104-250 from the human protein was used as the immunogen for the Cathepsin D antibody.
Storage: Store the Cathepsin D antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
