CTLA4 (Mouse), Fc-Fusion (Human), Avi-Tag, Biotin Labeled | 79001

CTLA4 (Mouse), Fc-Fusion (Human), Avi-Tag, Biotin Labeled | 79001 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Protein

Application: N/A

Background: The protein kinase c (PKC)/ Ca2+ response pathway leads to activation of the transcription factor nuclear factor of activator T cells (NFAT). NFAT is regulated by Ca2+ and the Ca2+/calmodulin-dependent serine phosphatase calcineurin. NFAT proteins are phosphorylated and reside in the cytoplasm in resting cells; upon stimulation, they are dephosphorylated by calcineurin, translocate to the nucleus, and induce gene expression.

Description: Mouse secreted CTLA4, with C-terminal Avi-Tag fused at the C-terminus with the Fc portion of human IgG1 and biotin labeled, also known as Cytotoxic T-lymphocyte-associated protein 4 and CD152. GenBank Accession No. NM_009843, a.a. 36-161 expressed in a HEK293 cell expression system. The protein is enzymatically biotinylated using AviTag™ technology. MW = 42 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.

Product Type: Protein

Shippement Condition: -80°C