Description
CTLA-4 Antibody / CD152 | V7700-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: L4P2F5.F10
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Mouse, Rat; Not suitable for Human samples testing.
Application: WB
Buffer: N/A
Limitation: This CTLA4 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: This CTLA4 antibody is specific to the soluble form of the protein. CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.
Immunogen: Amino acids CENAPNRARM were used as the immunogen for the CTLA4 antibody.
Storage: Store the CTLA4 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
