Description
CSEN Antibody / Calsenilin / KCNIP3 | F54703-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: IF, IHC-P, WB
Buffer: N/A
Limitation: This KCNIP3 antibody is available for research use only.
Purity: Purified
Description: KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.
Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for the KCNIP3 antibody.
Storage: Aliquot the KCNIP3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
