COMT Antibody | R31326

COMT Antibody | R31326 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC-P

Buffer: N/A

Limitation: This COMT antibody is available for research use only.

Purity: Antigen affinity

Description: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. It is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between the two forms reside within the N-termini.

Immunogen: An amino acid sequence from the N-terminus of human Catechol O-methyltransferase (DKKGKIVDAVIQEHQ) was used as the immunogen for this COMT antibody.

Storage: After reconstitution, the COMT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.