Cleaved-CASP4 p20 (Q81) Polyclonal Antibody | E-AB-30021

Cleaved-CASP4 p20 (Q81) Polyclonal Antibody | E-AB-30021 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Rabbit

Isotype: IgG

Application: WB, IHC-p, ELISA

Research Area: Cancer, Cell Biology, Metabolism

Background: This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

Lead Time: 2 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-4 p20

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000

Conjugation: Unconjugated

Calculated Molecular Weight: 43 kDa

Observed Molecular Weight: 43+22 kDa

Clonality: Polyclonal