Cleaved-CASP3 p17 (D175) Polyclonal Antibody | E-AB-30020

Cleaved-CASP3 p17 (D175) Polyclonal Antibody | E-AB-30020 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Application: WB, ELISA

Research Area: Cancer, Cell Biology, Metabolism, Neuroscience

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-3 p17

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.

Purification: Affinity purification

Dilution: WB 1:500-1:2000, ELISA 1:20000

Conjugation: Unconjugated

Calculated Molecular Weight: 32 kDa

Observed Molecular Weight: 17 kDa

Clonality: Polyclonal