Description
Claudin-6 CHO Cell Line (Low Expression) | 78527-L | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Cell Line
Application: Screen and validate antibodies against claudin-6 for drug discovery and research. Screen for compounds that regulate or inhibit claudin-6 signaling in a cellular context. Perform binding assays to screen for potential claudin-6 ligands.
Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-6 is one of the 27 members of the claudin family. Claudin-6 is widely expressed in various tumors but rarely expressed in healthy adult tissues. This cancer specific expression of claudin-6 makes it a promising target as an antigen for cancer immunotherapy. Several therapeutics that target claudin-6 are currently in development or in clinical trials including bispecific antibodies, monoclonal antibodies, and CAR-T cell therapy products.
Description: Recombinant clonal CHO cell line stably expressing full-length human claudin-6 (CLDN6 gene accession number NM_021195.5). Surface expression of claudin 6 was confirmed by flow cytometry. The stable clonal cell line was selected for high, medium, or low levels of claudin-6 expression compared to the parental CHO-K1 cell line.
Product Type: Cell Line
Shippement Condition: -80°C
