Description
Claudin-4 Lentivirus | 78723 | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Lentivirus
Application: Generate stable cell line expressing human Claudin-4 with puromycin selection
Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-4 is one of the 27 members of the Claudin family. Claudin-4 mediates paracellular chloride transport and plays an important renal function through the reabsorption of filtered chloride. The CLDN4 gene is deleted in Williams-Beuren syndrome, leading to multi-systemic neurodevelopmental disorders. The protein acts as a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) during infection by gram-positive Clostridial bacteria, which are responsible for food poisoning and gastrointestinal illnesses. Recent studies indicate that the protein may be overexpressed in ovarian cancer.
Description: The Claudin-4 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human Claudin-4 (NM_001305.5) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the Claudin-4 Lentivirus
Product Type: Lentivirus
Shippement Condition: -80°C
