Clasto-lactacystin β-lactone | 27224

Clasto-lactacystin β-lactone | 27224 | Gentaur US, UK & Europe Disrtribition

Category: Ubiquitination/Inhibitors / Activators

Application: N/A

Background: N/A

Description: Clasto-lactacystin β-lactone, also known as Omuralide and β-Clastolactacystin, targets ubiquitins. It is an active metabolite of lactacystin which induces differentiation and inhibition of cell cycle progression in several tumor cell lines. The inhibitor irreversibly alkylates subunit X of the 20s proteasome. Inhibition of proteasome peptidase activity results in the accumulation of various ubiquitinated proteins which normally undergo rapid degredation. Therefore, the effects are pleiotropic and largely depend on the expression patter of signaling proteins within the treated cell.

Product Type: Inhibitor

Shippement Condition: -20°C