Description
CK-6A/B/C Monoclonal Antibody | E-AB-22038 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human
Host: Mouse
Isotype: IgG
Application: WB, IHC-p, IF
Research Area: Cancer, Signal Transduction, Tags and Cell Markers
Background: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic Peptide
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification: Protein A purification
Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300
Conjugation: Unconjugated
Calculated Molecular Weight: 60 kDa
Observed Molecular Weight: 56-60 kDa
Clonality: Monoclonal
