Description
CK-17 Monoclonal Antibody | E-AB-22039 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human
Host: Mouse
Isotype: IgG
Application: WB, IHC-p, IF, IP
Research Area: Cancer, Signal Transduction
Background: May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic Peptide
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification: Protein A purification
Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300
Conjugation: Unconjugated
Calculated Molecular Weight: 48 kDa
Observed Molecular Weight: 48 kDa
Clonality: Monoclonal
