Description
Cisplatin | 27744 | Gentaur US, UK & Europe Disrtribition
Category: Apoptosis Inhibitor
Application: N/A
Background: Cisplatin induces cytotoxicity by interaction with DNA to form intrastrand crosslinks which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. Stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-?B content and translocation in macrophages.
Description: Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.
Product Type: Inhibitor
Shippement Condition: Room temp. (continental US) or gel packs
