CIITA Knockout THP-1 Cell Line | 78390

CIITA Knockout THP-1 Cell Line | 78390 | Gentaur US, UK & Europe Disrtribition

Category: CAR-T/Cell Line

Application: Study the consequences of losing MHC class II. Study T cell activation, antigen presentation, and immune responses. Useful for the development of improved universal CAR-T or other effector cells.

Background: CIITA (Class II Transactivator, also known as Class II Major Histocompatibility Complex Transactivator) acts as a coactivator for MHC class II-specific gene expression, and negatively regulates IL-4 expression during T cell differentiation. IFN-Ƴ induces CIITA gene expression via the JAK1 and STAT1 pathways. The GTP-binding and acidic, proline-serine-threonine rich regions of CIITA appear to be required for its activity. Defects in CIITA have been implicated in Bare Lymphocyte Syndrome (BLS), which is characterized by the absence of MHC class II transcription and severe immunodeficiencies. 

Description: CIITA (Class II Transactivator) has been genetically removed from THP-1 cells using CRISPR/Cas9 genome editing.

Product Type: Cell Line

Shippement Condition: -80°C