Description
Cig2 Antibody | V8291-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: 3A11/5
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Schizosaccharomyces pombe
Application: ELISA, WB
Buffer: N/A
Limitation: This Cig2 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Cig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type, S phase cyclin that is required for both the G1/S and G2/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1/S period. Cig2 binds to Cdc2 (Cdk), and the resulting Cdc2/Cig2 complex controls the G1/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF), and the protein is destroyed during anaphase by the APC/cyclosome (APC/C) and Skp1/Cullin-1/F-box (SCF), thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner, transcriptionally and post-translationally, while APC/C only destroys the protein.
Immunogen: Bacterial S. pombe Cig2 purified protein was used as the immunogen for the Cig2 antibody.
Storage: Store the Cig2 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
