CFTR Antibody / Cystic Fibrosis Transmembrane Regulator | V9382SAF-100UG

CFTR Antibody / Cystic Fibrosis Transmembrane Regulator | V9382SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: CFTR/7003R

Host: Rabbit

Clonality: Recombinant Rabbit Monoclonal

Isotype: Rabbit IgG, kappa

Species Reactivity: Human

Application: IHC-P

Application Details: Immunohistochemistry (FFPE): 1-2ug/ml

Application Note: Optimal dilution of the recombinant CFTR antibody should be determined by the researcher.

Purity: Protein A/G affinity

Description: Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Immunogen: A portion of amino acids 550-850 was used as the immunogen for the recombinant CFTR antibody.

Storage: Aliquot the recombinant CFTR antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Localization: Cell surface, Cytoplasm