CFTR Antibody / Cystic Fibrosis Transmembrane Regulator | V7216-20UG

CFTR Antibody / Cystic Fibrosis Transmembrane Regulator | V7216-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: CFTR1-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This CFTR antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Cystic fibrosis transmembrane conductance regulator (CFTR) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (MDR1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Immunogen: Human recombinant protein was used as the immunogen for this CFTR antibody.

Storage: Store the CFTR antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).