Description
CEACAM5 CHO Cell Line (Low Expression) | 78704-L | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling Pathway/Cell Line
Application: • Screen and validate antibodies against CEACAM5 for drug discovery and research. • Screen for compounds that regulate or inhibit CEACAM5 signaling in a cellular context. • Perform binding assays to screen for potential CEACAM5 ligands.
Background: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5, also known as CD66e) is a cell surface glycoprotein that serves as a cell adhesion protein. It has been used as a clinical biomarker to detect liver metastasis from gastrointestinal cancers and to predict gastrointestinal cancer relapse. CEACAM5 was recently identified as a potential target antigen for CAR T-cell therapy. Additionally, CEACAM5 may be involved in the inhibition of cell differentiation, apoptosis, and cell polarity.
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.
Product Type: Cell Line
Shippement Condition: -80°C
