CDK9/CyclinK, GST-tag | 40106

CDK9/CyclinK, GST-tag | 40106 | Gentaur US, UK & Europe Disrtribition

Category: Kinase-Serine/Threonine/Protein

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: CDK9/CyclinK is a member of the cyclin-dependent protein kinase (CDK) family. CDK9 is closely related to cdc28 and cdc2 and is an important regulator of the cell cycle (1). CDK9 is a component of the multiprotein complex TAK/P-TEFβ. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat protein which suggested a possible involvement of this protein in AIDS (2).

Description: Complex of recombinant human CDK9 and Cyclin K, full length, with N-terminal GST-tags, (GenBank Accession No. NM_001261, and BC015935, respectively) co-expressed in Sf9 insect cells via a baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C