Description
CDK6/CyclinD3 Kinase Assay Kit | 78395 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Assay Kit
Application: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: CDK6 is a serine/threonine protein kinase involved in cell cycle progression and in cellular differentiation. The CDK6/Cyclin D3 complex phosphorylate RB1 to release the transcription factor E2F and drive the transition from G1 to S-phase of the cell cycle. This complex regulates cell proliferation in many cell types and has been validated as a cancer therapeutic target. Palbociclib, a CDK4/CDK6 inhibitor, has shown therapeutic benefit in a small number of patients and is in clinical use for the treatment of ER+/HER2- breast cancer, with more clinical trials ongoing.
Description: The CDK6/CyclinD3 Kinase Assay Kit is designed to measure CDK6/CyclinD3 kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Product Type: Assay Kit
Shippement Condition: -80°C
