CDC7/DBF4 Complex | 100538

CDC7/DBF4 Complex | 100538 | Gentaur US, UK & Europe Disrtribition

Category: Kinase

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: CDC7 is a cell division cycle 7 homolog protein that is critical for the G1/S transition and is also essential for initiation of DNA replication as cell division occurs. CDC7 is expressed in many normal tissues, but the overexpression of CDC7 may be associated with neoplastic transformation for some tumors and transformed cell lines. CDC7/DBF4 kinase promotes S phase by alleviating an inhibitory activity in Mcm4 that evolved to integrate several protein kinase

Description: CDC7/DBF4 complex of human CDC7, also known as HsCDC7 and Hsk 1, GenBank Accession No. NM_003503 a.a. 1-574(end) with N-terminal GST-tag and MW= 94 kDa, and human DBF4, also known as ASK and CHIF, GenBank Accession No. NM_006716, a.a. 1-674(end) with N-terminal GST-tag and MW= 125 kDa, co-expressed expressed in an Sf9 infected baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C