CD99 Antibody Cocktail | V2711S-0.1ML

CD99 Antibody Cocktail | V2711S-0.1ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Bioreactor concentrate with 0.05% sodium azide

Format: Bioreactor concentrate

Clone: 12E7 + MIC2/877

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS, IF, IHC-P

Buffer: N/A

Limitation: This CD99 antibody cocktail is available for research use only.

Purity: Unpurified high titer supernatant

Description: Recognizes a sialoglycoprotein of 27-32kDa, identified as CD99, or MIC2 gene product, or E2 antigen. MIC2 gene is located in the pseudo-autosomal region of the human X and Y chromosome. MIC2 gene encodes two distinct proteins, which are produced by alternative splicing of the CD99 gene transcript and are identified as bands of 30 and 32kDa (p30/32). Although its function is not fully understood, CD99 is implicated in various cellular processes including homotypic aggregation of T cells, upregulation of T cell receptor and MHS molecules, apoptosis of immature thymocytes and leukocyte diapedesis. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. Most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells express this antigen. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing's sarcoma cells and primitive peripheral neuroectodermal tumors.

Immunogen: Human acute lymphocytic leukemia T-cells (12E7) and recombinant human protein (MIC2/877) were used as the immunogen for the CD99 antibody cocktail.

Storage: Store the CD99 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).