Description
CD59 Polyclonal Antibody | E-AB-13133 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human
Host: Rabbit
Isotype: IgG
Application: WB, IHC, ELISA
Research Area: Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells
Background: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.
Lead Time: 7~10 days
Concentration: 0.5 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human CD59
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:100-1:300
Conjugation: Unconjugated
Calculated Molecular Weight: 14 kDa
Observed Molecular Weight: N/A
Clonality: Polyclonal
