Description
CD59 Antibody | V3023-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: SPM616
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P
Buffer: N/A
Limitation: This CD59 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: CD59 is a glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, it can prevent C9 from polymerizing and forming the complement membrane attack complex. Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria. Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement. [Wiki]
Immunogen: Recombinant full-length human protein was used as the immunogen for the CD59 antibody.
Storage: Store the CD59 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
