Description
CD46(122.2), 0.2mg/mL Antibody | BNUB0175-100| Gentaur Distribution US, UK & Europe
Summary.: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. .
Conjugate: Purified, with BSA.
Storage Buffer: PBS, 0.05% BSA, 0.05% azide.
Storage Temperature: 2°C to 8°C.
Application: Flow (verified)|Flow, surface (published).
Stability: Stable at room temperature or 37°C (98°F) for 7 days.
