CD45(PTPRC), His-tag | 30044

CD45(PTPRC), His-tag | 30044 | Gentaur US, UK & Europe Disrtribition

Category: Protein Phosphatase/Receptor

Application: Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.

Background: PTPRC (CD45) contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. PTPRC has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.

Description: Protein tyrosine phosphatase CD45, also known as PTPRC (GenBank accession No. NM_080922), catalytic domain, a.a. 632-1304 (end) with N-terminal His-tag, MW=81 kDa, expressed in a Baculovirus Sf9 expression system.

Product Type: Protein

Shippement Condition: -80°C