Description
CD40 Antibody | V8350-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: FGK45.5
Host Animal: Rat
Clonality: Monoclonal (rat origin)
Species Reactivity: Mouse
Application: Functional Studies, FACS, IF
Buffer: N/A
Limitation: This CD40 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
Immunogen: Purified recombinant Mouse CD40 fusion protein was used as the immunogen for the CD40 antibody.
Storage: Store the CD40 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
