Description
CD38 (Mouse) Fluorogenic Assay Kit (Cyclase Activity) | 78285 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Assay Kit
Application: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD+) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic b cells, where it regulates insulin secretion. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia, and anti-CD38 antibodies are in clinical trials as therapeutics for multiple myeloma.
Description: The CD38 (Mouse) Inhibitor Screening Assay Kit (Cyclase Activity) is designed to measure the cyclase activity of CD38 (mouse) for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate nicotinamide guanine dinucleotide (NGD+), and CD38 assay buffer for 100 enzyme reactions. In addition, the kit includes the CD38 inhibitor quercetin for use as an inhibitor control.
Product Type: Assay Kit
Shippement Condition: -80°C
