CD31 Antibody / PECAM-1 | V8880-20UG

CD31 Antibody / PECAM-1 | V8880-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: C31.3 + JC/70A

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, IHC-P

Buffer: N/A

Limitation: This CD31 antibody is available for research use only.

Purity: Protein A/G affinity

Description: CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

Immunogen: Human recombinant CD31 protein (clone C31.3) & membrane preparation of a spleen from a patient with hairy cell leukemia (clone JC/70A) was used as the immunogen for the CD31 antibody.

Storage: Aliquot the CD31 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.