Description
CD30 Antibody | V2991S-0.1ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Bioreactor concentrate with 0.05% sodium azide
Format: Bioreactor concentrate
Clone: SPM121
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P
Buffer: N/A
Limitation: This CD30 antibody is available for research use only.
Purity: Unpurified high titer supernatant
Description: Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This mAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Immunogen: A Co cell line established from a patient with Hodgkin s disease of T-cell lineage was used as the immunogen for the CD30 antibody.
Storage: Store the CD30 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
