CD3 epsilon Antibody | V8795SAF-100UG

CD3 epsilon Antibody | V8795SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: rC3e/2479

Host: Mouse

Clonality: Recombinant Mouse Monoclonal

Isotype: Mouse IgG1, kappa

Species Reactivity: Human

Application: ELISA

Application Details: ELISA: 2-4ug/ml (for coating order BSA-free format)

Application Note: Optimal dilution of the CD3 epsilon antibody should be determined by the researcher.

Purity: Protein A/G affinity

Description: Recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

Immunogen: A portion of amino acids 23-119 was used as the immunogen for the CD3 epsilon antibody.

Storage: Aliquot the CD3 epsilon antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Localization: Cell Surface and cytoplasm