CD22 Antibody | V2984-20UG

CD22 Antibody | V2984-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: FR10B4

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: Functional studies, FACS, IF

Buffer: N/A

Limitation: This CD22 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: CD22 mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProt]

Immunogen: Human Burkitt’s lymphoma cells were used as the immunogen for the CD22 antibody.

Storage: Store the CD22 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).