CD20 Antibody Cocktail | V2392-0.1ML

CD20 Antibody Cocktail | V2392-0.1ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Bioreactor concentrate with 0.05% sodium azide

Format: Bioreactor concentrate

Clone: L26 + IGEL/733

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS, IF, IHC-P

Buffer: N/A

Limitation: This CD20 antibody cocktail is available for research use only.

Purity: Unpurified high titer supernatant

Description: This antibody recognizes a protein of 33-37kDa, identified as CD20 (Workshop V; Code CD20.12). The antibody recognizes the extracellular domain of the protein. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, Bcell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of Bcells and its expression is restricted to normal and neoplastic Bcells, being absent from all other leukocytes and tissues. It is expressed by pre Bcells and persists during all stages of Bcell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting Bcells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in Bcell activation and cell cycle progression.

Immunogen: Human tonsil B cells (L26) and recombinant protein (IGEL/733) were used as the immunogen for this CD20 antibody cocktail.

Storage: CD20 antibody cocktail with azide can be stored at 2-8oC. The azide-free format should be aliquoted and stored at -20 °C or colder.