CD18 Antibody / ITGB2 / LFA-1 | V2645-100UG

CD18 Antibody / ITGB2 / LFA-1 | V2645-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: 68-5A5

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: Functional studies, FACS, IF

Buffer: N/A

Limitation: This CD18 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: It recognizes a transmembrane glycoprotein of 95kDa, identified as CD18 or integrin -2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers, LFA-1, Mac-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This mAb blocks these cellular interactions.

Immunogen: Stimulated human leukocytes were used as the immunogen for the CD18 antibody.

Storage: Store the CD18 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).