Description
CD155 (PVR) - HEK293 Stable Cell Line | 60537 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: The CD155/HEK293 Stable Cell Line functions as an antigen-presenting cell (APC) to stimulate TIGIT-specific signaling responses in lymphocytes, such as cell proliferation and cytokine release, or with a TIGIT reporter cell line (BPS Cat. #60538).
Background: CD155 is a transmembrane glycoprotein receptor belonging to the immunoglobulin superfamily. It is highly expressed on dendritic cells, fibroblasts, endothelial cells, and multiple tumor cells including ovarian carcinoma, non-small cell lung, glioblastoma, and colorectal carcinoma. It has a high affinity for a T cell regulatory transmembrane surface protein called TIGIT (T cell immunoglobulin and ITIM domains), and plays a key role in tumor cell invasion and migration. Interaction between CD155 and TIGIT causes immunosuppressive effects on CD4+ and CD8+ T cells, which hinders T cell proliferation and function. CD155 also interacts with regulatory receptors CD226 (expressed on natural killer (NK) cells, monocytes and CD4+ T cells) and CD96. While CD155-CD226 engagement activates NK cell cytotoxicity and T cell response, CD155-CD96 interaction inhibits NK cell function. Due to these opposing regulatory effects, blockade of CD155-TIGIT and CD155- CD226 interactions are attractive therapeutic strategies in cancer immunotherapy and autoimmune diseases, respectively.
Description: Recombinant HEK293 cell line expressing full length human CD155, also known as poliovirus receptor (PVR) or nectin-like molecule-5 (NECL-5). Expression is confirmed by Western Blot.
Product Type: Cell Line
Shippement Condition: dry ice
