Description
CD146 Polyclonal Antibody | E-AB-40373 | Gentaur US, UK & Europe Disrtribition
Reactivity: Mouse, Rat
Host: Rabbit
Isotype: IgG
Application: IHC
Research Area: Immunology, Signal Transduction, Cancer, Stem Cells, Cardiovascular
Background: CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) .
Lead Time: 7~10 days
Concentration: 0.61 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant Rat Cell surface glycoprotein MUC18 protein
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3
Purification: Antigen Affinity Purification
Dilution: IHC 1:100-1:300
Conjugation: Unconjugated
Calculated Molecular Weight: N/A
Observed Molecular Weight: N/A
Clonality: Polyclonal
