CD146 Antibody / MCAM / MUC18 | V7943-100UG

CD146 Antibody / MCAM / MUC18 | V7943-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: MCAM/3046

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This MCAM antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

Immunogen: A recombinant human partial protein (amino acids 226-374) was used as the immunogen for the MCAM antibody.

Storage: Store the MCAM antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).