Description
CD146 Antibody / MCAM / MUC18 | V2698-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: C146/634
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: FACS, IF, IHC-P
Buffer: N/A
Limitation: This CD146 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: The human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Immunogen: Recombinant human protein was used as the immunogen for the CD146 antibody.
Storage: Store the CD146 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
